Abstract

Uterine fibroids (UFs) are non-cancerous tumors of the uterus that often lead to significant health issues such as bleeding, pain, and infertility. This study aimed to evaluate the effects of ginger extract on the lipid profile and liver function in uterine fibroid-induced rats. Thirty adult female Wistar albino rats were divided into three groups: a negative control group, a UF group, and a UF group treated with ginger ethanolic extract (GEE) at a dose of 100 mg/kg/day for six weeks. The results showed that rats with uterine fibroids exhibited significant biochemical alterations. Serum total cholesterol (T.C) was significantly elevated (273.3±7.4 mg/dl), along with triglycerides (T.G) (245.8±16.9 mg/dl), and low-density lipoprotein (LDL) (186.3±10 mg/dl), while high-density lipoprotein (HDL) levels were significantly decreased (37.3±1.02 mg/dl). Moreover, glucose levels were elevated (181.4±40.3 mg/dl), indicating metabolic dysfunction. In terms of liver function, there was a notable increase in liver enzyme activities: alanine aminotransferase (ALT) (74.2±7.11 U/L), aspartate aminotransferase (AST) (98.8±8.6 U/L), alkaline phosphatase (ALP) (164.4±7.4 U/L), and gamma-glutamyl transferase (GGT) (14.6±1.7 U/L), suggesting liver damage and dysfunction. Treatment with GEE (100 mg/kg/day) led to significant improvements in these parameters. Serum T.C was reduced to (127.7±6.6 mg/dl), T.G to (120.6±15 mg/dl), and glucose to (102.9±0.7 mg/dl). Furthermore, liver enzyme levels decreased significantly: ALT (40±3.3 U/L), AST (70.5±8.6 U/L), ALP (89±5.7 U/L), and GGT (7.5±0.6 U/L), suggesting the therapeutic potential of GEE. These results indicate that ginger extract has a beneficial effect in managing lipid metabolism and liver function in uterine fibroid-induced rats, demonstrating its potential as a therapeutic agent for uterine fibroids.

Keywords: 

Uterine fibroids, ginger extract, lipid profile, liver function, biochemical parameters.

Abstract

Helicobacter pylori(H. pylori) is a spiral shaped bacterium that lives and multiplies in the lining of the stomach, and it is a common cause of many stomach diseases including peptic ulcers.this study aims to show the effect of curcumin on helicobacter pylori in experimental rats .Sixty adulte male albino rats, weighting (140+10g) were randomly into six groups (10 rats each). as follows: Group (1): Comprised of normal rats as negative control groups(-ve), Group (2): Comprised of rats those were subjected to oral administration of curcuma aqueous extract (CAE) at a dose (200 mg/kg/day) . Group (3): Comprised of rats those were subjected to oral administration of curcuma aqueous extract (CAE) at a dose (400 mg/kg/day) .Group (4): Comprised of rats those were subjected  to injection of (1mL/rat) twice daily)  H. pylori act as a positive control(+ve).Group (5): Comprise of rats infected by H. pylori those were treated oral with at a dose (200 mg/kg/day) CAE andGroup (6): Comprise of rats infected by H. pylori those were treated oral with at a dose (400 mg/kg/day) CAE, for six weeks . At the end of the experiment, the rats were sacrificed, and serum was collected for biochemical analyses . Moreover The results revealed that curcuma aqueous extract 15Phenolic constituents . besides results indicated that the rats treated with curcuma aqueous extract 200 and 400 mg/kg/day showed significantly , decreases in serum cholesterol, triglycerides, glucose and LDL-C matched with significant increased in serum HDL-C, In addition , at (p≤0.05) there were decreased ,serum ALT, AST, ALP, and GGT, Also,  serum urea, creatinine, and uric acid levels, when compared with group (4), So this study recommended to use curcumin in diets for it is many benefits.

Keywords:

Helicobacter pylori(H. pylori), curcumin ,Antioxidant, Lipids profile and Liver and Kidney Function