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The Faculty of Pharmacy extends its heartfelt congratulations to the esteemed faculty members on their classification for research published in 2023, recognized among the most influential and distinguished scientists globally, according to the Stanford Un
Antioxidant and antidiabetic flavonoids from the leaves of Dypsis pembana (H.E.Moore) Beentje & J.Dransf., Arecaceae: in vitro and molecular docking studies
Research Abstract
Background: Oxidative stress and diabetes are medical conditions that have a growing prevalence worldwide, significantly impacting our bodies. Thus, it is essential to develop new natural antioxidant and antidiabetic agents. Dypsis pembana (H.E.Moore) Beentje & J.Dransf (DP) is an ornamental palm of the family Arecaceae. This study aimed to broaden the understanding of this plant's biological properties by evaluating its in vitro antioxidant and antidiabetic activities.
Methods: The in vitro antioxidant activities of the crude extract, fractions, and selected isolates were evaluated by DPPH method. While the in vitro antidiabetic activities of these samples were evaluated by assessing the degree of inhibition of α-glucosidase. Additionally, molecular docking analysis was performed to investigate the interactions of tested compounds with two potential targets, the cytochrome c peroxidase and alpha glucosidase.
Results: The crude extract displayed the highest antioxidant activity (IC50 of 11.56 µg/ml), whereas among the fractions, the EtOAc fraction was the most potent (IC50 of 14.20 µg/ml). Among tested compounds, isoquercetrin (10) demonstrated the highest potency, with an IC50 value of 3.30 µg/ml, followed by rutin (8) (IC50 of 3.61 µg/ml). Regarding antidiabetic activity, the EtOAc (IC50 of 60.4 µg/ml) and CH2Cl2 fractions (IC50 of 214.9 µg/ml) showed activity, while the other fractions did not demonstrate significant antidiabetic effects. Among tested compounds, kaempferol-3-O-neohesperidoside (9) showed the highest antidiabetic activity, with an IC50 value of 18.38 µg/ml, followed by kaempferol (4) (IC50 of 37.19 µg/ml). These experimental findings were further supported by molecular docking analysis, which revealed that isoquercetrin and kaempferol-3-O-neohesperidoside exhibited strong enzyme-binding affinities to the studied enzyme targets. This analysis provided insights into the structure-activity relationships among the investigated flavonol-O-glycosides.
Conclusion: The biological and computational findings revealed that isoquercetrin and kaempferol-3-O-neohesperidoside have potential as lead compounds for inhibiting cytochrome c peroxidase and alpha glucosidase enzymes, respectively.
Research Date
Research Department
Research Journal
BMC Complementary Medicine and Therapies
Research Member
Research Year
2023
Tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (THTT), A Versatile Carrier System for Targeting Cell Cycle Checkpoint Pathways with Potential Anticancer Activities
Research Date
Research Department
Research Journal
11th Edition of Global Conference on Pharmaceutics and Novel Drug Delivery Systems
Research Member
Research Publisher
Magnus Group Conferences and Organizing Committee
Research Website
https://pharmaceuticsconference.com/speaker/tarek-aboul-fadl
Research Year
2024
The deadline for submitting research abstracts has been extended until Thursday, October 10, 2024, for the 14th International Conference on Pharmaceutical Sciences at Assiut University.
The deadline for submitting research abstracts has been extended until Thursday, October 10, 2024, for the 14th International Conference on Pharmaceutical Sciences at Assiut University.
The conference is scheduled to take place on Wednesday and Thursday, November 6-7, 2024, in the Administrative Building at Assiut University.
Registration link for the conference:
https://forms.gle/K6G1GmAEFvTNDHMd7
The subscription fee and payment methods are detailed as stated.
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خبر عام
Congratulations on the New Academic Year
Prof. Dr. Gihan Nabil Hassan Fetih, Acting Dean of the Faculty, along with the vice deans and department heads, extends heartfelt congratulations to all the students of the Faculty for the new academic year 2024-2025.
We wish you a year filled with success, excellence, and creativity.
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خبر عام
To Allah we belong and to Him we shall return
To Allah we belong and to Him we shall return. The Faculty of Pharmacy, Assiut University, mourns the passing of Mr. Badri Shakli Muhammad, Service Assistant, Department of Clinical Pharmacy. May God have mercy on the deceased and forgive him, and may the family offer our sincere condolences. To God we belong and to Him we shall return.
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خبر عام
Lecture and practical lessons schedule for the first year of the Clinical Pharmacy Program, Faculty of Pharmacy and Pharmaceutical Research, National University, first semester of the academic year 2024/2025
توزيع مجموعات المحاضرات النظرية
|
مجموعة |
الطلاب |
|
|
من |
ألى |
|
|
مجموعة (أ) |
1 |
160 |
|
مجموعة (ب) |
161 |
320 |
|
مجموعة (ج) |
321 |
إلى الآخر |
توزيع مجموعات الدروس العملية
|
المجموعة |
الطلاب |
|
|
من |
ألى |
|
|
مجموعة (أ) |
1 |
120 |
|
مجموعة (ب) |
121 |
240 |
|
مجموعة (ج) |
241 |
360 |
|
مجموعة (د) |
361 |
إلى الآخر |
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خبر عام
The Faculty of Pharmacy has completed its preparations for the new academic year 2024/2025
under the patronage of His Excellency Prof. Dr. Ahmed El-Manshawy, President of the University,
and Prof. Dr. Ahmed Mohamed Abd El-Mawly, Vice President for Education and Student Affairs.
On Tuesday, September 2024, Prof. Dr. Gihan Nabil Hassan Fetih, Acting Dean of the Faculty, accompanied by Prof. Dr. Hassan Refaat Hassan, Faculty Vice Dean for Education and Student Affairs, Prof. Dr. Mohamed Mahmoud Abdel Latif, Faculty Vice Dean for Community Service and Environmental Development, and Mr. Tarek Said, Faculty Secretary, conducted an inspection tour of the lecture halls and laboratories across various departments. They ensured that all educational needs and quality elements were met, all maintenance work was completed, and schedules for all study levels were announced, ensuring the smooth operation of the educational process.
news category
خبر عام
Announcement to students Clinical Pharmacy Program Schedule for the first semester of the academic year 2024/2025
The schedule for the first semester of the academic year has been set. 2024/2025 as follows:
Registration deadline for first semester courses is Sunday 29-9-2024 until Sunday 6/10/2024
The date for dropping and adding courses for the first semester is from Monday Corresponding to 7/10 to Monday 14/7/2024.
The deadline for withdrawal from courses with a refund of fees is Tuesday 15-10 until Monday 21/10/2024 and the withdrawal date from Courses without refund from Tuesday until 22/10/2024
The student will be considered to have failed if he withdraws after this date Sunday 27-10-2024
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إعلانات الطلاب